PUBLIKATIONEN

Originalarbeiten

[45] Wohlfart, S., Herth, J., Böhmann, M.B., Pander, G., Herbster, L., Mier, W., Auffarth, G. U., Uhl, P., Hammer, M. “Exposure to silicone oil endotamponades induces VEGF antibody aggregation and loss of functionality”, IOVS, accepted.

[44] Hammer, M., Britz, L., Böhmann, M.B., Herbster, L., Muuss, M., Herth, J., Cionoiu, S., Krisp, H., Spitzer, M.S., Wohlfart, S., Uhl, P., Auffarth, G.U. “Early silicone oil opacification in the absence of emulsification is caused by an increased level of silicone dioxide”, RETINA, accepted.

[43] Werner, J., Umstätter, F., Böhmann, M.B., Müller, H., Beijer, B., Hertlein, T., Kaschnitz, L., Bram, L., Kleist, C., Klika, K.D., Mühlberg, E., Braune, G., Wohlfart, S., Gärtner, M., Peter, S., Zimmermann, S., Haberkorn, U., Ohlsen, K., Brötz-Oesterhelt, H., Mier, W., Uhl, P. “Conjugation of polycationic peptides extends the efficacy spectrum of β-lactam antibiotics“, Advanced Science, accepted.

[42] Hammer, M., Herth, J., Herbster, L., Böhmann, M.B., Muuss, M., Khoramnia, R., Scheuerle, A., Mier, W., Wohlfart, S., Auffarth, G.U., Uhl, P. “Physicochemical and Pharmacokinetic Properties of Bevacizumab Dissolved in Silicone Oils compared to Hydrogel-Substitutes and Porcine Vitreous Bodies“, Gels, accepted manuscript.

[41] Hammer, M., Britz, L., Schickhardt, S., Munro, D., Khoramnia, R., Scheuerle, A., Mayer, C.S., Uhl, P., Łabuz, G., Auffarth, G.U. “Straylight of explanted Silicone Oil Samples to predict Emulsification”, Ophthalmology Science, accepted manuscript.

[40] Hammer, M., Muuss, M., Herbster, L., Herth, J., Scheuerle, A., Khoramnia, R., Labuz, G., Uhl, P., Auffarth, G. “Viscoelastic, optical and surgical properties of vitreous body replacement hydrogels after aging compared to porcine vitreous bodies and silicone oils”, TVST, accepted manuscript.

[39] Hammer, M., Muuss, M., Schickhardt, S., Scheuerle, A., Khoramnia, R., Labuz, G., Uhl, P., Auffarth, G.U. “Forward Light Scattering of the vitreous body after enzymatic aging: An in-vitro model to study vitreous opacification”, Investigative Ophthalmology & Visual Science (2024), accepted manuscript.

[38] Werner, J., Umstätter, F., Hertlein, T., Mühlberg, E., Beijer, B., Wohlfart, S., Zimmermann, S., Haberkorn, U., Ohlsen, K., Fricker, G., Mier, W. & Uhl, P. “Oral delivery of the vancomycin derivative FU002 by a surface-modified liposomal nanocarrier“, Advanced Healthcare Materials (2024), accepted manuscript

[37] Werner, J., Umstätter, F., Hertlein, T., Beijer, B., Kleist, C., Mühlberg, E., Zimmermann, S., Haberkorn, U., Ohlsen, K., Fricker, G., Mier, W., & Uhl, P. “Improved pharmacokinetics and enhanced efficacy of the vancomycin derivative FU002 using a liposomal nanocarrier“, Nanomedicine NBM (2023), accepted manuscript.

[36] Hartl, N., Gabold, B., Uhl, P., Kromer, A., Xiao, X., Mier, W., Liu, R., Merkel, O.A. “ApoE – Functionalization of Nanoparticles for Targeted Brain Delivery – A Feasible Method for Polyplexes?” Drug Delivery and Translational Research (2023), accepted manuscript. PMID: 38087181.

[35] Hammer, M., Britz, L., Schickhardt, S., Lieberwirth, I., Munro, D., Uhl, P., Scheuerle, A., Khoramnia, R., Łabuz, G., Auffarth, G.U. “Quantification of straylight induced by silicone oil adherent to intraocular lenses of different materials.” American Journal of Ophthalmology (2023), accepted manuscript.

[34] Dürr, V., Wohlfart, S., Eisenzapf, T., Mier, W., Fricker, G., Uhl, P. “Oral Delivery of mRNA by Liposomes Functionalized with Cell-Penetrating Peptides”, Applied Nano 4 (2023), 293-308. https://doi.org/10.3390/applnano4040017

[33] Hammer, M., Herth, J., Muuss, M., Schickhardt, S., Scheuerle, A., Khoramnia, R., Labuz, G., Uhl, P., Auffahrt, G.U. “Forward light scattering of first to third generation vitreous body replacement hydrogels after surgical application compared to conventional silicone oils and vitreous body”, Gels, 9 (2023), 837. PMID: 37888410.

[32] Hammer, M., Schickhardt, S., Munro, D., Scheuerle, A., Khoramnia, R., Uhl, P., Auffarth, G.U. “New approaches to explanting high-viscosity silicone oil in retinal surgery – Polyimide cannulas vs extraction sleeves vs a luer-trocar.” International Journal of Retina and Vitreous. 9 (2023), 43. PMID: 37488630.

[31] Hartl, N., Gabold, B., Adams, F., Uhl, P., Oerter, S., Gätzner, S., Metzger, M., König, A.C., Hauck, S.M., Appelt-Menzel, A., Mier, W., Fricker, G., Merkel, O.M. “ Overcoming the Blood-Brain Barrier? Prediction of Blood-Brain Permeability of Hydrophobically Modified Polyethylenimine Polyplexes for siRNA Delivery into the Brain with in vitro and in vivo models.” Journal of Controlled Release. 360 (2023), 613-629. PMID: 37437848.

[30] Uhl, P., Bajraktari-Sylejmani, G., Witzigmann, D., Zimmermann, S., Burhenne, J., Wiess, J., Heafeli, W.E., Sauter, M. “A nanocarrier approach for oral peptide delivery: evaluation of cell-penetrating-peptide modified liposomal formulations in dogs”, Advanced Therapeutics. 2023, 2300021. https://doi.org/10.1002/adtp.202300021.

[29] Uhl, P. “Online statt Präsenz: Umarbeitung des Seminars „Pharmazeutische Toxikologie“ in ein Online-Format anhand des „Scholarship of Teaching“ HINT. Heidelberg Inspirations for Innovative Teaching 3 (2022), 167-186. https://doi.org/10.11588/hint.2022.1.92857

[28] Umstätter, F., Werner, J., Zerlin, L., Mühlberg, E., Kleist, C., Klika, K. D., Hertlein, T., Beijer, B., Domhan, C., Zimmermann, S., Ohlsen, K., Haberkorn, U., Mier, W. & Uhl, P. “Impact of Linker Modification and PEGylation of Vancomycin Conjugates on Structure-Activity Relationships and Pharmacokinetics.” Pharmaceuticals 15 (2022), 159. PMID: 35215272

[27] Hammer, M., Schickhardt, S. K., Merz, P. R., Khoramnia, R., Scheuerle, A. F., Mier, W., Uhl, P. & Auffarth, G. U. “Intravitreal Application: Physicochemical Properties of Drugs Dissolved in Silicone Oils of Different Density in Comparison to the Porcine Vitreous Body.” Pharmaceutics 14 (2022), 1364. PMID: 35890260.

[26] Benzel, J., Bajraktari-Sylejmani, G., Uhl, P., Davis, A., Nair, S., Pfister, S.M., Haefeli, W.E., Weiss, J., Burhenne, J., Pajtler, K.W. & Sauter, M. “Investigating the Central Nervous System Disposition of Actinomycin D: Implementation and Evaluation of Cerebral Microdialysis and Brain Tissue Measurements Supported by UPLC-MS/MS Quantification.“ Pharmaceutics 13 (2021): 1498. PMID: 34575574

[25] Pratsinis A., Uhl, P., Bolten, J.S., Hauswirth, P., Schenk, S.H., Urban, S., Mier, W., Witzigmann, D. & Huwyler J. “Virus-Derived Peptides for Hepatic Enzyme Delivery.” Molecular Pharmaceutics 18 (2021), 2004-2014. PMID: 33844553

[24] Uhl, P. et al. “Overcoming the Mucosal Barrier: Tetraether Lipid-Stabilized Liposomal Nanocarriers Decorated with Cell-Penetrating Peptides Enable Oral Delivery of Vancomycin” Advanced Therapeutics 4 (2021). https://doi.org/10.1002/adtp.202000247

[23] Storck, P., Umstätter, F., Wohlfart, S., Domhan, C., Kleist, C., Werner, J., Brandenburg, K., Zimmermann, S., Haberkorn, U., Mier, W. & Uhl, P. “Fatty Acid Conjugation Leads to Length-Dependent Antimicrobial Activity of a Synthetic Antibacterial Peptide (Pep19-4LF).“ Antibiotics 9 (2020), 844. PMID: 33255900

[22] Sauter M., Uhl, P., Burhenne J., Haefeli WE. “Application of triple quadrupole tandem mass spectrometry to the bioanalysis of collision-induced dissociation-resistant cyclic peptides − Ultra-sensitive quantification of the somatostatin-analog pasireotide utilizing UHPLC-MS/MS.” Journal of Pharmaceutical and Biomedical Analysis 5 (2020), 113728. PMID: 33234413

[21] Sauter, M., Burhenne, J., Haefeli, W.E. & Uhl, P. “An Underestimated Factor: The Extent of Cross-Reactions Modifying APIs in Surface-Modified Liposomal Preparations Caused by Comprised Activated Lipids.” Molecules 25 (2020), E4436. PMID: 32992540

[20] Mühlberg, E., Umstätter, F., Domhan, C., Hertlein, T., Ohlsen, K., Krause, A., Kleist, C., Beijer, B., Zimmermann, S., Haberkorn, U., Mier, W. & Uhl, P. “Vancomycin-Lipopeptide Conjugates with High Antimicrobial Activity on Vancomycin-Resistant Enterococci.” Pharmaceuticals (Basel). 2020 May 29;13(6):110. PMID: 32485876

[19] Sauter, M., Uhl, P., Burhenne, J. & Haefeli, WE. “Ultra-sensitive quantification of the therapeutic cyclic peptide bremelanotide utilizing UHPLC-MS/MS for evaluation of its oral plasma pharmacokinetics.“ Journal of Pharmaceutical and Biomedical Analalysis 15 (2020), 113276. PMID: 32353679

[18] Sauter, M., Uhl, P., Meid, A.D., Mikus, G., Burhenne, J. & Haefeli, WE. “New insights into the pharmacokinetics of vancomycin after oral and intravenous administration: An investigation in beagle dogs.“ Journal of Pharmaceutical Sciences 109 (2020), 2090-2094, PMID: 32201235

[17] Umstätter, F.; Domhan, C., Hertlein, T., Ohlsen, K., Mühlberg, E., Kleist, C., Zimmermann, S., Beijer, B., Klika, K.D., Haberkorn, U., Mier, W. & Uhl, P. “Inside Back Cover: Vancomycin Resistance Is Overcome by Conjugation of Polycationic Peptides (Angewandte Chemie Internationale Edition 23/2020).“ https://doi.org/10.1002/anie.202004925

[16] Umstätter, F.; Domhan, C., Hertlein, T., Ohlsen, K., Mühlberg, E., Kleist, C., Zimmermann, S., Beijer, B., Klika, K.D., Haberkorn, U., Mier, W. & Uhl, P. “Überwindung von Vancomycinresistenzen durch Modifikation mit polykationischen Peptiden.“ Angewandte Chemie 2020. https://doi.org/10.1002/ange.202002727

[15] Umstätter, F.; Domhan, C., Hertlein, T., Ohlsen, K., Mühlberg, E., Kleist, C., Zimmermann, S., Beijer, B., Klika, K.D., Haberkorn, U., Mier, W. & Uhl, P. “Vancomycin Resistance is Overcome by Conjugation of Polycationic Peptides.“ Angewandte Chemie Internationale Edition 59 (2020), 8823-8827. PMID: 32190958

[14] Sauter, M., Uhl, P., Burhenne, J. & Haefeli, WE. “Post-extraction disulfide bond cleavage for MS/MS quantification of collision-induced dissociation-resistant cystine-cyclized peptides and its application to the ultra-sensitive UPLC-MS/MS bioanalysis of octreotide in plasma.” Analytica Chimica Acta 1114 (2020), 42-49. PMID: 32359513

[13] Schuster, L., Sauter, M., Uhl, P., Meid, A., Haefeli, W.E., Weiss, J. & Theile, D. “Reporter cell assay-based functional quantification of TNF-α-antagonists in serum — a proof-of-principle study for adalimumab.”  Analytical Biochemistry 596 (2020), 113646., PMID: 32112722

[12] Sauter, M., Uhl, P., Haefeli, WE. & Burhenne, J. “Ultra-sensitive bioanalysis of the therapeutic peptide exenatide for accurate pharmacokinetic analysis at effective plasma concentrations utilizing UPLC-MS/MS.” Journal of Pharmaceutical Analysis 10 (2020), 233-239. PMID: 32612869

[11] Uhl, P. et al. “Coating of PLA-nanoparticles with cyclic, arginine-rich cell penetrating peptides enables oral delivery of liraglutide.” Nanomedicine: Nanotechnology, Biology and Medicine Nanomedicine. 2020:102132. PMID: 31783138

[10] Domhan, C., Uhl, P., Kleist, C., Zimmermann, S., Umstätter, F., Leotta, K., Mier, W. & Wink, M. “Replacement of l-Amino Acids by d-Amino Acids in the Antimicrobial Peptide Ranalexin and Its Consequences for Antimicrobial Activity and Biodistribution.” Molecules 24 (2019), E2987. PMID: 31426494

[9] Witzigmann, D., Uh, P., Sieber, S., Kaufman, C., Einfalt, T., Schöneweis, K., Grossen, P., Buck, J., Ni, Y., Schenk, S.H., Hussner, J., Meyer zu Schwabedissen, H.E., Quebatte, G., Mier, W., Urban, S. & Huwyler, J. “Optimization-by-design of hepatotropic lipid nanoparticles targeting the sodium-taurocholate cotransporting polypeptide.” Elife 2019, e42276. PMID: 31333191

[8] Sauter M., Uhl, P., Foerster, K.I., Mohr, I., Höne, R.T. Merle, U. Burhenne, J. & Haefeli WE. “An ultra-sensitive UHPLC-MS/MS assay for the quantification of orally administered vancomycin in plasma.” Journal of Pharmaceutical and Biomedical Analysis, 174 (2019), 633-638. PMID: 31279892

[7] Sauter, M., Uhl, P. , Majewsky, M., Fresnais, M., Haefeli, W.E. & Burhenne, J. “An ultrasensitive UPLC–MS/MS assay for the quantification of the therapeutic peptide liraglutide in plasma to assess the oral and nasal bioavailability in beagle dogs.” Bioanalysis 11 (2019), 887-898. PMID: 31094209

[6] Sieber, S., Grossen, P., Uhl, P. , Detampel. P., Mier, W., Witzigmann, D. & Huwyler, J. “Zebrafish as a predictive screening model to assess macrophage clearance of liposomes in vivo.” Nanomedicine: Nanotechnology, Biology and Medicine 17 (2019), 82-93. PMID: 30659929

[5] Kruse, S., Büchler, M., Uhl, P., Sauter, M., Scherer, P., Lan, T.C.T., Zottnick, S., Klevenz, A., Yang, R., Rösl, F., Mier, W. & Riemer, AB. “Therapeutic vaccination using minimal HPV16 epitopes in a novel MHC-humanized murine HPV tumor model.” OncoImmunology, 8 (2018), e1524694. PMID: 30546964

[4] Domhan, C., Uhl, P., Meinhardt, A., Zimmermann, S., Kleist, C., Lindner, T., Leotta, K., Mier, W. & Wink, M. “A novel tool against multiresistant bacterial pathogens–lipopeptide modification of the natural antimicrobial peptide ranalexin for enhanced antimicrobial activity and improved pharmacokinetics.” International Journal of Antimicrobial Agents 52 (2018), 52-62. PMID: 29649587

[3] Uhl, P. et al. “Oral delivery of vancomycin by tetraether lipid liposomes.“ European Journal of Pharmaceutical Sciences 108 (2017), 111-118. PMID: 28716758

[2] Tremmel, R., Uhl, P. , Helm, F., Wupperfeld, D:, Sauter, M., Mier, W., Stremmel, W., Hofhaus, G. & Fricker, G. “Delivery of Copper-chelating Trientine (TETA) to the central nervous system by surface modified liposomes.“ International Journal of Pharmaceutics, 512 (2016), 87-95. PMID: 27553779

[1] Uhl, P. et al. “A liposomal formulation for the oral application of the investigational hepatitis B drug Myrcludex B.“ European Journal of Pharmaceutics and Biopharmaceutics 103 (2016), 159-166. PMID: 27049970