Originalarbeiten
[63] Müller, H., Werner, J., Guther, J., Straetener, J., Böhmann, M.B., Uhl, P. & Brötz-Oesterhelt, H. “Synergistic mode of action of a ceftazidime-hexa-arginine-conjugate with resistance-overcoming properties”, Microbiology Spectrum, accepted.
[62] Pander, G., del Pilar Palacios Cisneros, M., Certa, C., Stierli, M., Beck, K., Färber, N., Blank, L., Tanner, F., Mühlberg, E., Wohlfart, S., Kleist, C., Huwyler, J., Fricker, G., Mier, W., Uhl, P. “ Balancing stealth and targetability: cCPP- and PEG-modified liposomes for the targeted delivery of anti-HER2 nanobodies”, Advanced Science, accepted.
[61] Bay, C., Mühlberg, E., Uhl, P., Stingel, J., Bajraktari-Sylejmani, G., Burhenne, J., Weiss, J., Sauter, M. „Novel paracellular marker based on ᴅ-dipeptide structure for highly sensitive quantification with UPLC-MS/MS for in vitro and in vivo blood-brain barrier permeability analysis“, Fluids and Barriers of the CNS, 2026, accepted.
[60] Gericke, B., Uhl, P., Fricker, G. “Effect of Glyphosate and AMPA on expression and activity of ABC export proteins in killifish (Fundulus heteroclitus) kidney tubules”, Environmental Toxicology and Pharmacology, accepted.
[59] Karaivanova, M., Łabuz, G., Zielinska, A., Zhiyi, W., Britz, L., Wohlfart, S., Uhl, P., Auffarth, G.U., Hammer, M. „The effect of the capsular bag on the optical performance of an IOL measured in an ex-vivo model“, IOVS, 2026, accepted.
[58] Hammer, M., Geisweid, L., Junker, N., Wohlfart, S., Skrzypczyk, L., Ackermann, B. C., Herth, J., Studier-Fischer, A., Mier, W., Augustin, V.A., Auffarth, G.U. & Uhl, P. “In-depth analysis of the intravitreal biocompatibility of polyethylene glycol of different molecular weight in an in-vivo porcine model”, IOVS, 2026, accepted.
[57] Sedlmayr, V., Meid, A.D., Mühlberg, E., Böhmann, M.B., Quehenberger, J., Wurm, D., Gynther, M., Spadiut, O., Fricker, G. & Uhl, P. “Beyond PEGylation: Archaeal Lipids for Long-Circulating Liposomes “, Advanced NanoBiomed Research, 2026, accepted.
[56] Ackermann, B.C., Skrzypczyk, L., Geisweid, L., Junker, N., Wohlfart, S., Uhl, P., Auffarth, G.U., Augustin, V.A. & Hammer, M. “Increasing dark adaption times and ERG response in landrace pigs – An intraindividual comparison in 20 animals”, Experimental Eye Research.
https://doi.org/10.1016/j.exer.2025.110733→
[55] Rehra, L., Erdinger, S., Wagner, L., Baltissen, D., Just, J., König, L., Mühlberg, E., Eisenzapf, T., Kilian, L., Banicevic, M., Bengelsdorff, V., Buchholz, C.J., Mier, W., Uhl, P., Korte, M., Fricker, G. & Müller, U.C. “Brain delivery of a neurotrophic peptide derived from secreted Amyloid Precursor Protein APPsα as a therapeutic strategy for Alzheimer’s disease”, Journal of Controlled Release. https://doi.org/10.1016/j.jconrel.2025.114374→
[54] Hammer, M., Skrzypczyk, L., Wohlfart, S., Ackermann, B.C., Geisweid, L., Pohl, S.W., Karaivanova, M., Herth, J., Augustin, V.A., Studier-Fischer, A., Sackmann, T., Kaulen, L., Steyer, A., Mier, W., Steel, D.H., Xue, K., Auffarth, G.U. & Uhl, P. “Methotrexate-loaded liposomal formulation enables 6-week sustained intraocular therapeutic drug release in a porcine model”, Advanced Healthcare Materials, accepted, belongs to “Rising Stars” Edition. https://doi.org/10.1002/adhm.202503230→
[53] Skrzypczyk, L., Ackermann, B.C., Geisweid, L., Wohlfart, S., Junker, N., Augustin, V.A., Rahn, U., Herth, J., Uhl, P., Auffarth, G.U., Hammer, M. “An in-depth characterization of development-related electroretinographical and morphological changes in landrace pigs”, Documenta Ophthalmologica, accepted. https://doi.org/10.1016/j.ejps.2025.107159→
[52] Kruse, S., Fricke, L.T., Zottnick, S., Schlosser, A., Grabowska, A., Feidt, E., Uhl, P., Junglas, E., Förster, J.D., Blersch J., Denner, P., Günter, M., Autenrieth S.E., Fava, E., Mier, W., Kübelbeck, A., Riemer, A.B. “A versatile silica nanoparticle platform for induction of T cell responses – applied for therapeutic vaccination against HPV16 E6/E7-positive tumors in MHC-humanized mice”, OncoImmunology, (2025). https://doi.org/10.1016/j.ejps.2025.107159→
[51] Cindy Bay, Philipp Uhl, Andreas D. Meid, Jürgen Burhenne, Walter E. Haefeli, Max Sauter. „Quantification of Arginine-Rich Cyclic Cell-Penetrating Peptide–Lipid Conjugates Using a Surrogate Peptide Extracted by Phospholipase D Digestion and Trifluoroacetic Acid-Based UPLC-MS/MS Analysis“, Analytical Chemistry, (2025) accepted. https://doi.org/10.1016/j.ejps.2025.107159→
[50] C. Pfaffendorf; K. Sackmann; J. Mischlinger; J. Dejon-Agobé; O. Maïga-Ascofaré; E. Ahenkan; A. Adegnika; M. Ramharter; P. Uhl.; G. Fricker, S. Wicha.“ Development and Application of an LC-MS/MS Method for Quantification of Fosmidomycin in Human and Rat Plasma”, Malaria Journal, (2025) accepted. https://doi.org/10.1016/j.ejps.2025.107159→
[49] Muuss, M., Karaivanova, M., Skrzypczyk, L., Wohlfart, S., Herth, J., Uhl, P., Auffarth, G.U., Hammer, M. “F4H5 alleviates increased outflow resistance induced by emulsified silicone oil in vitro”, IOVS, 2025 accepted. https://doi.org/10.1016/j.ejps.2025.107159→
[48] Sedlmayr, V., Quehenberger, J., Wurm, D., Gynther, M., Vieth, R., Dürr, V., Gesse, P., Spadiut, O., Fricker, G. & Uhl, P. “Archaeosomal nanocarriers improve pharmacokinetics and bioavailability of vancomycin after oral administration”, European Journal of Pharmaceutical Sciences, 2025, accepted. https://doi.org/10.1016/j.ejps.2025.107159→
[47] Herbster, L., Pander, G., Böhmann, M., Eisenzapf, T., Wohlfahrt, S., Mier, W., Fricker, G. & Uhl, P. „Liposomes containing tetraether lipids and cell penetrating peptides as platform technology for oral delivery of peptides? A comparative study on GLP-1 analogues”, Nano Select, (2025) accepted.
https://doi.org/10.1002/nano.70010
[46] Umstätter, F., Rasheed, S., Mühlberg, E., Beijer,B., Hertlein, T., Klika, K.D., Kleist, C., Werner, J., Domhan, C., Müller, A., Rausch, M., Zimmermann, S., Ohlsen, K., Haberkorn, U., Koch, M., Bischoff, M., Schneider, T., Müller, R., Herrmann, J., Mier, W., & Uhl, P. “One Step Ahead of Bacteria: Daptomycin-Peptide Conjugates Acquire an Ancillary Calcium-Independent Mechanism of Action“, Advanced Therapeutics, accepted. (2025) https://doi.org/10.1002/nano.70010→
[45] Wohlfart, S., Herth, J., Böhmann, M.B., Pander, G., Herbster, L., Mier, W., Auffarth, G. U., Uhl, P., Hammer, M. “Exposure to silicone oil endotamponades induces VEGF antibody aggregation and loss of functionality”, IOVS, 65 (2024), 56-56. https://doi.org/10.1167/iovs.65.13.56→
[44] Hammer, M., Britz, L., Böhmann, M.B., Herbster, L., Muuss, M., Herth, J., Cionoiu, S., Krisp, H., Spitzer, M.S., Wohlfart, S., Uhl, P., Auffarth, G.U. “Early silicone oil opacification in the absence of emulsification is caused by an increased level of silicone dioxide”, RETINA (2024), 10-1097. PMID: 39527946.
[43] Werner, J., Umstätter, F., Böhmann, M.B., Müller, H., Beijer, B., Hertlein, T., Kaschnitz, L., Bram, L., Kleist, C., Klika, K.D., Mühlberg, E., Braune, G., Wohlfart, S., Gärtner, M., Peter, S., Zimmermann, S., Haberkorn, U., Ohlsen, K., Brötz-Oesterhelt, H., Mier, W., Uhl, P. “Conjugation of polycationic peptides extends the efficacy spectrum of β-lactam antibiotics“, Advanced Science, 11 (2024), 2411406. PMID: 39499737. https://doi.org/10.1002/advs.202411406→
[42] Hammer, M., Herth, J., Herbster, L., Böhmann, M.B., Muuss, M., Khoramnia, R., Scheuerle, A., Mier, W., Wohlfart, S., Auffarth, G.U., Uhl, P. “Physicochemical and Pharmacokinetic Properties of Bevacizumab Dissolved in Silicone Oils compared to Hydrogel-Substitutes and Porcine Vitreous Bodies“, Gels, 10 (2024), 501. PMID: 39195030. https://doi.org/10.3390/gels10080501→
[41] Hammer, M., Britz, L., Schickhardt, S., Munro, D., Khoramnia, R., Scheuerle, A., Mayer, C.S., Uhl, P., Łabuz, G., Auffarth, G.U. “Straylight of explanted Silicone Oil Samples to predict Emulsification”, Ophthalmology Science, 4 (2024), 100558. PMID: 39132022. https://doi.org/10.1016/j.xops.2024.100558→
[40] Hammer, M., Muuss, M., Herbster, L., Herth, J., Scheuerle, A., Khoramnia, R., Labuz, G., Uhl, P., Auffarth, G. “Viscoelastic, optical and surgical properties of vitreous body replacement hydrogels after aging compared to porcine vitreous bodies and silicone oils”, TVST, 13 (2024). PMID: 38967936 https://doi.org/10.1167/tvst.13.7.5→
[39] Hammer, M., Muuss, M., Schickhardt, S., Scheuerle, A., Khoramnia, R., Labuz, G., Uhl, P., Auffarth, G.U. “Forward Light Scattering of the vitreous body after enzymatic aging: An in-vitro model to study vitreous opacification”, Investigative Ophthalmology & Visual Science, 65 (2024), 36-36. PMID: 38551585. https://doi.org/10.1167/iovs.65.3.36 →
[38] Werner, J., Umstätter, F., Hertlein, T., Mühlberg, E., Beijer, B., Wohlfart, S., Zimmermann, S., Haberkorn, U., Ohlsen, K., Fricker, G., Mier, W. & Uhl, P. “Oral delivery of the vancomycin derivative FU002 by a surface-modified liposomal nanocarrier“, Advanced Healthcare Materials, 13 (2024), 2303654. PMID: 38387090. https://doi.org/10.1002/adhm.202303654→
[37] Werner, J., Umstätter, F., Hertlein, T., Beijer, B., Kleist, C., Mühlberg, E., Zimmermann, S., Haberkorn, U., Ohlsen, K., Fricker, G., Mier, W., & Uhl, P. “Improved pharmacokinetics and enhanced efficacy of the vancomycin derivative FU002 using a liposomal nanocarrier“, Nanomedicine NBM, 56 (2023), 102731. PMID: 38158147. https://doi.org/10.1016/j.nano.2023.102731→
[36] Hartl, N., Gabold, B., Uhl, P., Kromer, A., Xiao, X., Mier, W., Liu, R., Merkel, O.A. “ApoE – Functionalization of Nanoparticles for Targeted Brain Delivery – A Feasible Method for Polyplexes?” Drug Delivery and Translational Research, 14 (2023), 1660-1677. PMID: 38087181. https://doi.org/10.1007/s13346-023-01482-w→
[35] Hammer, M., Britz, L., Schickhardt, S., Lieberwirth, I., Munro, D., Uhl, P., Scheuerle, A., Khoramnia, R., Łabuz, G., Auffarth, G.U. “Quantification of straylight induced by silicone oil adherent to intraocular lenses of different materials.” American Journal of Ophthalmology, 262 (2023), 192-198. PMID: 38016528. https://doi.org/10.1016/j.ajo.2023.11.018 →
[34] Dürr, V., Wohlfart, S., Eisenzapf, T., Mier, W., Fricker, G., Uhl, P. “Oral Delivery of mRNA by Liposomes Functionalized with Cell-Penetrating Peptides”, Applied Nano 4 (2023), 293-308. https://doi.org/10.3390/applnano4040017 →
[33] Hammer, M., Herth, J., Muuss, M., Schickhardt, S., Scheuerle, A., Khoramnia, R., Labuz, G., Uhl, P., Auffahrt, G.U. “Forward light scattering of first to third generation vitreous body replacement hydrogels after surgical application compared to conventional silicone oils and vitreous body”, Gels, 9 (2023), 837. PMID: 37888410. https://doi.org/10.3390/gels9100837→
[32] Hammer, M., Schickhardt, S., Munro, D., Scheuerle, A., Khoramnia, R., Uhl, P., Auffarth, G.U. “New approaches to explanting high-viscosity silicone oil in retinal surgery – Polyimide cannulas vs extraction sleeves vs a luer-trocar.” International Journal of Retina and Vitreous. 9 (2023), 43. PMID: 37488630. https://doi.org/10.1186/s40942-023-00481-w→
[31] Hartl, N., Gabold, B., Adams, F., Uhl, P., Oerter, S., Gätzner, S., Metzger, M., König, A.C., Hauck, S.M., Appelt-Menzel, A., Mier, W., Fricker, G., Merkel, O.M. “ Overcoming the Blood-Brain Barrier? Prediction of Blood-Brain Permeability of Hydrophobically Modified Polyethylenimine Polyplexes for siRNA Delivery into the Brain with in vitro and in vivo models.” Journal of Controlled Release. 360 (2023), 613-629. PMID: 37437848. https://doi.org/10.1016/j.jconrel.2023.07.019→
[30] Uhl, P., Bajraktari-Sylejmani, G., Witzigmann, D., Zimmermann, S., Burhenne, J., Wiess, J., Heafeli, W.E., Sauter, M. “A nanocarrier approach for oral peptide delivery: evaluation of cell-penetrating-peptide modified liposomal formulations in dogs”, Advanced Therapeutics. 2023, 2300021. https://doi.org/10.1002/adtp.202300021→
[29] Uhl, P. “Online statt Präsenz: Umarbeitung des Seminars „Pharmazeutische Toxikologie“ in ein Online-Format anhand des „Scholarship of Teaching“ HINT. Heidelberg Inspirations for Innovative Teaching 3 (2022), 167-186. https://doi.org/10.11588/hint.2022.1.92857→
[28] Umstätter, F., Werner, J., Zerlin, L., Mühlberg, E., Kleist, C., Klika, K. D., Hertlein, T., Beijer, B., Domhan, C., Zimmermann, S., Ohlsen, K., Haberkorn, U., Mier, W. & Uhl, P. “Impact of Linker Modification and PEGylation of Vancomycin Conjugates on Structure-Activity Relationships and Pharmacokinetics.” Pharmaceuticals 15 (2022), 159. PMID: 35215272. https://doi.org/10.3390/ph15020159→
[27] Hammer, M., Schickhardt, S. K., Merz, P. R., Khoramnia, R., Scheuerle, A. F., Mier, W., Uhl, P. & Auffarth, G. U. “Intravitreal Application: Physicochemical Properties of Drugs Dissolved in Silicone Oils of Different Density in Comparison to the Porcine Vitreous Body.” Pharmaceutics 14 (2022), 1364. PMID: 35890260. https://doi.org/10.3390/pharmaceutics14071364→
[26] Benzel, J., Bajraktari-Sylejmani, G., Uhl, P., Davis, A., Nair, S., Pfister, S.M., Haefeli, W.E., Weiss, J., Burhenne, J., Pajtler, K.W. & Sauter, M. “Investigating the Central Nervous System Disposition of Actinomycin D: Implementation and Evaluation of Cerebral Microdialysis and Brain Tissue Measurements Supported by UPLC-MS/MS Quantification.“ Pharmaceutics 13 (2021): 1498. PMID: 34575574. https://doi.org/10.3390/pharmaceutics13091498 →
[25] Pratsinis A., Uhl, P., Bolten, J.S., Hauswirth, P., Schenk, S.H., Urban, S., Mier, W., Witzigmann, D. & Huwyler J. “Virus-Derived Peptides for Hepatic Enzyme Delivery.” Molecular Pharmaceutics 18 (2021), 2004-2014. PMID: 33844553. https://doi.org/10.1021/acs.molpharmaceut.0c01222 →
[24] Uhl, P. et al. “Overcoming the Mucosal Barrier: Tetraether Lipid-Stabilized Liposomal Nanocarriers Decorated with Cell-Penetrating Peptides Enable Oral Delivery of Vancomycin” Advanced Therapeutics 4 (2021). https://doi.org/10.1002/adtp.202000247 →
[23] Storck, P., Umstätter, F., Wohlfart, S., Domhan, C., Kleist, C., Werner, J., Brandenburg, K., Zimmermann, S., Haberkorn, U., Mier, W. & Uhl, P. “Fatty Acid Conjugation Leads to Length-Dependent Antimicrobial Activity of a Synthetic Antibacterial Peptide (Pep19-4LF).“ Antibiotics 9 (2020), 844. PMID: 33255900. https://doi.org/10.3390/antibiotics9120844 →
[22] Sauter M., Uhl, P., Burhenne J., Haefeli WE. “Application of triple quadrupole tandem mass spectrometry to the bioanalysis of collision-induced dissociation-resistant cyclic peptides − Ultra-sensitive quantification of the somatostatin-analog pasireotide utilizing UHPLC-MS/MS.” Journal of Pharmaceutical and Biomedical Analysis 5 (2020), 113728. PMID: 33234413. https://doi.org/10.1016/j.jpba.2020.113728 →
[21] Sauter, M., Burhenne, J., Haefeli, W.E. & Uhl, P. “An Underestimated Factor: The Extent of Cross-Reactions Modifying APIs in Surface-Modified Liposomal Preparations Caused by Comprised Activated Lipids.” Molecules 25 (2020), E4436. PMID: 32992540. https://doi.org/10.3390/molecules25194436 →
[20] Mühlberg, E., Umstätter, F., Domhan, C., Hertlein, T., Ohlsen, K., Krause, A., Kleist, C., Beijer, B., Zimmermann, S., Haberkorn, U., Mier, W. & Uhl, P. “Vancomycin-Lipopeptide Conjugates with High Antimicrobial Activity on Vancomycin-Resistant Enterococci.” Pharmaceuticals (Basel). 2020 May 29;13(6):110. PMID: 32485876. https://doi.org/10.3390/ph13060110 →
[19] Sauter, M., Uhl, P., Burhenne, J. & Haefeli, WE. “Ultra-sensitive quantification of the therapeutic cyclic peptide bremelanotide utilizing UHPLC-MS/MS for evaluation of its oral plasma pharmacokinetics.“ Journal of Pharmaceutical and Biomedical Analalysis 15 (2020), 113276. PMID: 32353679. https://doi.org/10.1016/j.jpba.2020.113276 →
[18] Sauter, M., Uhl, P., Meid, A.D., Mikus, G., Burhenne, J. & Haefeli, WE. “New insights into the pharmacokinetics of vancomycin after oral and intravenous administration: An investigation in beagle dogs.“ Journal of Pharmaceutical Sciences 109 (2020), 2090-2094, PMID: 32201235. https://doi.org/10.1016/j.xphs.2020.03.012 →
[17] Umstätter, F.; Domhan, C., Hertlein, T., Ohlsen, K., Mühlberg, E., Kleist, C., Zimmermann, S., Beijer, B., Klika, K.D., Haberkorn, U., Mier, W. & Uhl, P. “Inside Back Cover: Vancomycin Resistance Is Overcome by Conjugation of Polycationic Peptides (Angewandte Chemie Internationale Edition 23/2020). https://doi.org/10.1002/anie.202004925 →
[16] Umstätter, F.; Domhan, C., Hertlein, T., Ohlsen, K., Mühlberg, E., Kleist, C., Zimmermann, S., Beijer, B., Klika, K.D., Haberkorn, U., Mier, W. & Uhl, P. “Überwindung von Vancomycinresistenzen durch Modifikation mit polykationischen Peptiden.“ Angewandte Chemie 2020. . https://doi.org/10.1002/ange.202002727 →
[15] Umstätter, F.; Domhan, C., Hertlein, T., Ohlsen, K., Mühlberg, E., Kleist, C., Zimmermann, S., Beijer, B., Klika, K.D., Haberkorn, U., Mier, W. & Uhl, P. “Vancomycin Resistance is Overcome by Conjugation of Polycationic Peptides.“ Angewandte Chemie Internationale Edition 59 (2020), 8823-8827. PMID: 32190958 . https://doi.org/10.1002/anie.202002727→
[14] Sauter, M., Uhl, P., Burhenne, J. & Haefeli, WE. “Post-extraction disulfide bond cleavage for MS/MS quantification of collision-induced dissociation-resistant cystine-cyclized peptides and its application to the ultra-sensitive UPLC-MS/MS bioanalysis of octreotide in plasma.” Analytica Chimica Acta 1114 (2020), 42-49. PMID: 32359513. https://doi.org/10.1016/j.aca.2020.04.016 →
[13] Schuster, L., Sauter, M., Uhl, P., Meid, A., Haefeli, W.E., Weiss, J. & Theile, D. “Reporter cell assay-based functional quantification of TNF-α-antagonists in serum — a proof-of-principle study for adalimumab.” Analytical Biochemistry 596 (2020), 113646., PMID: 32112722. . https://doi.org/10.1016/j.ab.2020.113646→
[12] Sauter, M., Uhl, P., Haefeli, WE. & Burhenne, J. “Ultra-sensitive bioanalysis of the therapeutic peptide exenatide for accurate pharmacokinetic analysis at effective plasma concentrations utilizing UPLC-MS/MS.” Journal of Pharmaceutical Analysis 10 (2020), 233-239. PMID: 32612869. . https://doi.org/10.1016/j.jpha.2020.02.008→
[11] Uhl, P. et al. “Coating of PLA-nanoparticles with cyclic, arginine-rich cell penetrating peptides enables oral delivery of liraglutide.” Nanomedicine: Nanotechnology, Biology and Medicine Nanomedicine, 24 (2020):102132. PMID: 31783138. . https://doi.org/10.1016/j.nano.2019.102132→
[10] Domhan, C., Uhl, P., Kleist, C., Zimmermann, S., Umstätter, F., Leotta, K., Mier, W. & Wink, M. “Replacement of l-Amino Acids by d-Amino Acids in the Antimicrobial Peptide Ranalexin and Its Consequences for Antimicrobial Activity and Biodistribution.” Molecules 24 (2019), E2987. PMID: 31426494. . https://doi.org/10.3390/molecules24162987→
[9] Witzigmann, D., Uh, P., Sieber, S., Kaufman, C., Einfalt, T., Schöneweis, K., Grossen, P., Buck, J., Ni, Y., Schenk, S.H., Hussner, J., Meyer zu Schwabedissen, H.E., Quebatte, G., Mier, W., Urban, S. & Huwyler, J. “Optimization-by-design of hepatotropic lipid nanoparticles targeting the sodium-taurocholate cotransporting polypeptide.” Elife 2019, e42276. PMID: 31333191. https://doi.org/10.7554/eLife.42276→
[8] Sauter M., Uhl, P., Foerster, K.I., Mohr, I., Höne, R.T. Merle, U. Burhenne, J. & Haefeli WE. “An ultra-sensitive UHPLC-MS/MS assay for the quantification of orally administered vancomycin in plasma.” Journal of Pharmaceutical and Biomedical Analysis, 174 (2019), 633-638. PMID: 31279892. https://doi.org/10.1016/j.jpba.2019.06.015→
[7] Sauter, M., Uhl, P. , Majewsky, M., Fresnais, M., Haefeli, W.E. & Burhenne, J. “An ultrasensitive UPLC–MS/MS assay for the quantification of the therapeutic peptide liraglutide in plasma to assess the oral and nasal bioavailability in beagle dogs.” Bioanalysis 11 (2019), 887-898. PMID: 31094209. https://doi.org/10.4155/bio-2018-0322→
[6] Sieber, S., Grossen, P., Uhl, P. , Detampel. P., Mier, W., Witzigmann, D. & Huwyler, J. “Zebrafish as a predictive screening model to assess macrophage clearance of liposomes in vivo.” Nanomedicine: Nanotechnology, Biology and Medicine 17 (2019), 82-93. PMID: 30659929. https://doi.org/10.1016/j.nano.2018.11.017→
[5] Kruse, S., Büchler, M., Uhl, P., Sauter, M., Scherer, P., Lan, T.C.T., Zottnick, S., Klevenz, A., Yang, R., Rösl, F., Mier, W. & Riemer, AB. “Therapeutic vaccination using minimal HPV16 epitopes in a novel MHC-humanized murine HPV tumor model.” OncoImmunology, 8 (2018), e1524694. PMID: 30546964. https://doi.org/10.1080/2162402X.2018.1524694→
[4] Domhan, C., Uhl, P., Meinhardt, A., Zimmermann, S., Kleist, C., Lindner, T., Leotta, K., Mier, W. & Wink, M. “A novel tool against multiresistant bacterial pathogens–lipopeptide modification of the natural antimicrobial peptide ranalexin for enhanced antimicrobial activity and improved pharmacokinetics.” International Journal of Antimicrobial Agents 52 (2018), 52-62. PMID: 29649587. https://doi.org/10.1016/j.ijantimicag.2018.03.023→
[3] Uhl, P. et al. “Oral delivery of vancomycin by tetraether lipid liposomes.“ European Journal of Pharmaceutical Sciences 108 (2017), 111-118. PMID: 28716758. https://doi.org/10.1016/j.ejps.2017.07.013→
[2] Tremmel, R., Uhl, P. , Helm, F., Wupperfeld, D:, Sauter, M., Mier, W., Stremmel, W., Hofhaus, G. & Fricker, G. “Delivery of Copper-chelating Trientine (TETA) to the central nervous system by surface modified liposomes.“ International Journal of Pharmaceutics, 512 (2016), 87-95. PMID: 27553779. https://doi.org/10.1016/j.ijpharm.2016.08.040→
[1] Uhl, P. et al. “A liposomal formulation for the oral application of the investigational hepatitis B drug Myrcludex B.“ European Journal of Pharmaceutics and Biopharmaceutics 103 (2016), 159-166. PMID: 27049970. https://doi.org/10.1016/j.ejpb.2016.03.031 →
Übersichtsartikel
[12] Blank, L., Pander, G., Mühlberg, E., Mier, W. & Uhl, P. Exploiting the unique properties of Nanobodies: Enhancing therapeutics, drug delivery and targeted diagnostics, Drug Discovery Today, 2025. https://doi.org/10.1016/j.drudis.2025.104524→
[11] Drescher, S., De Rosa, G., Prakash, J., Sauvage, F., Uhl, P. & Wibel, R. Special Issue: Phospholipids as Functional Ingredients in Pharmaceutical Formulations: Current Advances and Perspectives, European Journal of Pharmaceutical Sciences, 2025. https://doi.org/10.1016/j.ejps.2025.107334→
[10] Mühlberg, E., Fricker, G., & Uhl, P. Can nanoparticulate formulations of vancomycin and vancomycin derivatives improve antibiotic therapy? Nanomedicine, 1–4. (2025) https://doi.org/10.1080/17435889.2025.2500905→
[9] Pander, G., Uhl, P., Kühl, N., Haberkorn, U., Anderl, J. & Mier, W. “Antibody–drug conjugates: what drives their progress?” Drug Discovery Today 27 (2022), 103311. PMID: 35787480 https://doi.org/10.1016/j.drudis.2022.06.011→
[8] Mühlberg E., Burtscher, M., Umstätter, F., Fricker, G., Mier, W. & Uhl, P. “Trends in liposomal nanocarrier strategies for the oral delivery of biologics.”, Nanomedicine 16 (2021), 1813-1832. PMID: 34269068
https://doi.org/10.2217/nnm-2021-0177→
[7] Uhl, P., Umstätter, F., Domhan, C., Hertlein, T., Ohlsen, K., Zimmermann, S. & Mier, W. “Bakterielle Resistenzen überwinden – Reaktivierung etablierter Antibiotika mittels Peptidkonjugation” Wiley Analytical Sciences 2021. https://analyticalscience.wiley.com/do/10.1002/was.000600074/full/→
[6] Uhl, P. et al. “Eine Strategie zur Überwindung von Vancomycin-Resistenzen.” Pharmakon 4/2020.
[5] Mühlberg, E., Umstätter, F., Kleist, C., Domhan, C., Mier, W. & Uhl, P. “Renaissance of Vancomycin: Approaches for Breaking Antibiotic-Resistance in Multidrug-Resistant Bacteria.” Canadian Journal of Microbiology 66 (2020), 11-16. PMID: 31545906 https://doi.org/10.1139/cjm-2019-0309→
[4] Uhl, P. “Schnell oder langsam – wie sich die Freisetzung von Arzneistoffen modifizierten lässt.” Deutsche Apotheker Zeitung 28 (2019), p. 48f, 11.07.2019
[3] Uhl, P., Haberkorn, U., & Mier, W. “Frühe Diagnosen durch PET.” Deutsche Apotheker Zeitung 29 (2015) p. 50f, 16.07.2015
[2] Uhl, P., Fricker, G., Haberkorn, U. & Mier, W. “Radionuclides in drug development.“ Drug Discovery Today 20 (2015), 198-208. PMID: 25304182
https://doi.org/10.1016/j.drudis.2014.09.027→
[1] Uhl, P., Fricker, G., Haberkorn, U. & Mier, W. “Current status in the therapy of liver diseases.“ International Journal of Molecular Sciences 15 (2014), 7500-7512. PMID: 24786290 https://doi.org/10.3390/ijms15057500→
Patente
[11] Hyaluronic acid-based hydrogels for use as vitreous body substitute, EP25205764.1
[10] “Liposomal methotrexate formulations for intravitreal application” – (EP25153850.0)
[9] “A composition comprising a mixture of at least one oil and one or more semifluorinated alkanes, a use of the composition for treating a desease as well as a method of producing the composition and corresponding kits” (EP24174853.2)
[8] “Hydrogels for use as vitreous body substitute” (EP24168938.9)
[7] “Oral pharmaceutical compositions comprising lipid conjugates” (PCT/EP2021/069648)
[6] “Method of making oral dosage forms“ (EP3628309A1)
[5]“Improved polypeptide coupled antibiotics“ (EP19769720.4)
[4] “Liposomal compositions and solid dosage forms comprising the same“ (WO/2018/178395)
[3] “Coating of nanoparticle surfaces with cyclopeptides for improving delivery of agents“ (WO2018065085A1)
[2] “Liposomes containing cell penetrating peptides and tetraether lipids for the oral delivery of macromolecules“ (WO/2017/067642)
[1] “Novel liposomal formulation for the oral hepatic delivery of drugs“ (WO2017067640A1)
Preise:
- PHOENIX Pharmazie Wissenschaftspreis 2025: Kategorie Pharmazeutische Technologie für die Publikation „Oral Delivery of the Vancomycin Derivative FU002 by a
Surface-Modified Liposomal Nanocarrier“ in Advanced Healthcare Materials. https://www.phoenixgroup.eu/de/wissenschaftspreis→ - Galenus Support 2025
(Galenus-Privatstiftung, Wien): Dermaler Drug Delivery. - Hörst-Böhme-Preis 2024 (DPhG-Preis für Nachwuchswissenschaftler) (Münster): Reaktivierung und Formulierung von Antibiotika
- Gewinner Ideenphase Science for Life 2024 (Frankfurt): Projekt “VitreoSub”
- hei_INNOVATION Ideenwettbewerb 2023 (Heidelberg): Projekt „ROVANCE“
- Hengstberger-Preis für den wissenschaftlichen Nachwuchs 2022 (Heidelberg): Projekt „ROVANCE“
- Galenus Technologie-Preis 2021 (Galenus Privatstiftung, Wien): Oralisierung von Peptid-Therapeutika
- Galenus Support 2020 (Galenus Privatstiftung, Wien): Oralisierung von Peptid-Therapeutika
- Thudichum Award for Young Scientists (6th Symposium on Phospholipids in Pharmaceutical Research 2019, Heidelberg): Oralisierung von Peptid-Therapeutika
- Posterpreis: “5th Symposium on Phospholipids in Pharmaceutical Research 2017” mit dem Poster: “Cell penetrating liposomes enable oral delivery of vancomycin” (Phospholipid Research Center, Heidelberg)
- Gewinner Ideen Phase Science for Life 2017 (Frankfurt): Projekt “LipOra”
- PHOENIX Pharmazie Wissenschaftspreis 2025: Kategorie Pharmazeutische Technologie für die Publikation „Oral Delivery of the Vancomycin Derivative FU002 by a





